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Rogue AI Agent Escaped Its Test and Hacked Hugging Face, OpenAI Reveals

· Free Press Journal

An autonomous artificial intelligence (AI) agent powered by OpenAI technology escaped a controlled testing environment, accessed the open internet and independently hacked AI startup Hugging Face in what the company described as an "unprecedented incident".

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OpenAI said the agent, designed to perform tasks without human intervention, breached Hugging Face's systems before the startup detected and contained the intrusion.

"We consider this incident to be an unprecedented cyber incident, involving state-of-the-art cyber capabilities," OpenAI said.

The company warned that such incidents could become more common as AI models, which power chatbots and autonomous agents, grow increasingly capable, The Guardian reports.

Agent exploited unknown flaw to access internet

According to OpenAI, the incident involved a combination of its latest publicly available model, GPT-5.6 Sol, and a more advanced model that has not yet been released.

The models were undergoing internal cybersecurity testing inside a secure digital sandbox when they identified a previously unknown vulnerability. Exploiting the flaw allowed them to gain access to the open internet.

The AI agent then infiltrated Hugging Face, a repository of AI models, in an attempt to obtain technology that would improve its performance in the hacking evaluation. OpenAI said the models "successfully found ways to gain access to secret information that it could use to cheat the evaluation". The breach ended after Hugging Face's security team, assisted by its own AI agents, detected and stopped the activity.

Hugging Face Chief Executive Clément Delangue described the incident as "mind-blowing" but said he believed there was "no malicious intent" from OpenAI.

"We suspected last week's cyber-attack might have come from a frontier lab, given the sophistication of the agent," he wrote on X.

Incident renews AI safety concerns

An undiscovered software flaw is known as a zero-day vulnerability because developers have no time to fix it before it can be exploited. Earlier this year, Anthropic said its Mythos model had identified thousands of such vulnerabilities.

The disclosure prompted the US government to restrict exports of Mythos and its companion model, Fable 5, before later lifting the restrictions. GPT-5.6 Sol was also subject to similar export controls before becoming available globally.

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US Congressman Greg Casar said the episode underscored the need for stronger oversight of advanced AI systems.

"AI is developing extremely fast with no real regulations to keep us safe," he said in a statement calling for mandatory independent safety testing, mandatory disclosure of security incidents and international cooperation "to keep people safe from absolute disaster".

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Pancreatic cancer vaccine shows promise in first human trial, preventing disease in high-risk patients

· Fox News

A new vaccine for the prevention of pancreatic cancer has shown promise in an early study at Johns Hopkins School of Medicine in Baltimore, Maryland.

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A phase 1 trial published in Cancer Discovery, a journal of the American Association for Cancer Research, tested an experimental vaccine called mKRAS-VAX in 20 people, according to a press release.

Participants had an inherited risk of pancreatic ductal adenocarcinoma (PDAC), the most common and aggressive form of pancreatic cancer, along with an abnormality detected in imaging, typically a pancreatic cyst. These individuals had not been diagnosed with pancreatic cancer.

NEW PANCREATIC CANCER PILL NEARLY DOUBLES SURVIVAL TIME IN BREAKTHROUGH TRIAL

Four injections were administered to participants during weeks one, three and five, along with a booster at week 13.

The vaccine targeted six common mutations of KRAS. Changes in this gene drive more than 90% of PDACs.

The vaccine triggered a mutant KRAS-targeted immune response in 18 of the 20 participants (90%). On average, immune activity increased about 18-fold, although responses varied. Half of participants responded to all six KRAS mutations included in the vaccine.

Researchers also found the vaccine generated two types of T cells — one to attack abnormal cells and another to provide longer-term immune memory.

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The vaccine appeared to be safe, with participants experiencing only injection-site reactions and temporary flu-like symptoms.

While the phase 1 trial was designed primarily to evaluate safety rather than effectiveness, after about 16.5 months of follow-up, no participants had developed pancreatic cancer. At the same time, 37.5% of vaccinated participants experienced shrinkage or disappearance of the pancreatic cysts that had put them at increased risk for the disease.

Study co-author Neeha Zaidi, MD, associate professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, commented that the long-lasting response of this vaccine is "particularly noteworthy when assessing for possible interception of cancer, which requires long-lasting immunity."

"In addition, the vaccine was safe and well-tolerated, supporting its use in larger cancer interception studies," she said in the press release. "Overall, this study represents the first proof of concept for the use of vaccines for interception of pancreatic cancer in human patients."

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Co-author Michael G. Goggins, MD, professor of pathology, medicine and oncology and the Sol Goldman Professor of Pancreatic Cancer Research at Johns Hopkins University School of Medicine, also commented on the findings.

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"We observed evidence of stability or regression of the pancreatic cysts in association with the induction and durability of KRAS-specific T-cell responses," he said in the release. "However, larger studies are needed to demonstrate that this effect was in fact due to the vaccine."

The authors noted the study was limited by its small sample size and because it was not designed to determine clinical efficacy.

Fellow senior author Elizabeth Jaffee, MD, deputy director of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, commented that prevention and interception "save lives and reduce the morbidity associated with cancer development and progression."

"This is especially important for cancers whose early-onset frequency is increasing and for which we do not have effective methods for early detection," she added in the release.

Jaffee noted that this research highlights the need for more funding to support developing strategies for preventing cancer in high-risk individuals.

"More studies are needed to find the best vaccine approaches, the best targets and the ideal timing for vaccination," she said.

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We've Been Wrong About Nuclear Power

· Reason

Zion Lights is a former spokesperson for the radical environmental group Extinction Rebellion, whose members are known for causing mass transportation stoppages and gluing themselves to planes to call attention to what they say is a "climate and ecological emergency." She has gone from protesting nuclear power plants to aggressively campaigning for their expansion as a way of helping the global poor raise their living standards.

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Raised in Great Britain by working-class immigrants from rural Punjab, her new book is Energy Is Life: Why Environmentalism Went Nuclear. She talks with Nick Gillespie about how she came to reject the ubiquitous arguments against nuclear energy she encountered as a child, how guilt-ridden countries such as Germany are increasing pollution by shutting down nuclear power, and why oil-rich Gulf States are betting on renewable and clean energy sources.

 

0:00—The significance of a saucepan

5:15—Thesis of Energy is Life

9:07—Prosperity and guilt

17:38—Extinction Rebellion

21:36—Hostility toward nuclear energy

27:35—The safety of nuclear energy

31:10—France and Germany

36:56—Zion's revelation on nuclear energy

43:57—The nuclear energy industry

50:50—China and the United Arab Emirates

53:16—Energy policy

56:42—Taking technology for granted

The post We've Been Wrong About Nuclear Power appeared first on Reason.com.

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